Researchers have identified a molecular switch that turns on allergic reactions to food allergies in humans, causing diseases such as asthma, eczema, and.

A recent study by a scientist at the University of Texas MD Anderson Cancer Center, Houston, has identified the molecular agent responsible for managing immune cells develop the ability to produce an allergic reaction. The molecular agent, called thymic stromal lymphopoietin (TSLP), is the cause of the occurrence of allergic diseases like asthma, atopic dermatitis (eczema) and food allergy in humans, researchers say, but how it could happen ?

Well, according to researchers, dendritic cells, immune cells that initiate primary immune responses play an important role in the mechanism of allergic reaction. When dendritic cells come in contact with other immune cells, T cells, they induce T cells to develop into different categories, such as helper 1 (Th1) and helper 2 ( Th2) cells, the researchers said. The types of T cells are responsible for initiating protective immune responses, but Th2 cells can also initiate an allergic reaction in itself according to the study. it has never been known before how dendritic cells interact with them regularly on T cells to become Th2 cells, the researchers said.

The blood of healthy donors were used by investigators to isolate the dendritic cells (University of Texas). It was discovered by scientists that the binding of TSLP to cells activate a unique set of signaling pathways in cells. A direct result of this path is the production of messenger molecules by dendritic cells that act on T cells, causing T cells to develop into Th2 cells, (University of Texas).

Therefore, the study identifies TSLP as a molecular switch that triggers the development of allergic reactions in humans, suggesting that this molecule may be a target for effective treatment or prevention of allergic diseases, such as the above future.

Drugs can be developed to block the actions of TSLP. Not only that, understanding the function such a molecule will one day pave the way for the development of medicinal agents that could potentially reverse the allergic reaction in humans.

There are millions of people worldwide who suffer from illnesses related bodi?? S allergic reaction (asthma and allergies Foundation of America (AAFA)). Asthma is a disease. This is the most common of all chronic obstructive pulmonary disease (Current opinion in lung Medicine: January 2008 – Volume 14 – Issue 1 p – 3-8).

Diabetes is characterized by chronic inflammation of the lungs causing respiratory or bronchial narrowing (AAFA). This causes students difficulty breathing, (AAFA). Current drug target against asthma airway inflammation and narrowing of lung problems. But this is a temporary solution to a chronic problem. Drugs or vaccines developed to target the molecule TSLP other hand could be a major step forward in the treatment or effective in the treatment of asthma.

Eczema is an inflammatory process that occurs in shallow (Dorland?? S Medical Dictionary (DMD)). This was especially the epidermis (DMD). Eczema is characterized by redness, itching, minute papules and vesicles, weeping, oozing and crusting, and later through the level, and often pigmentation, dystrophy (DMD). The description of the symptoms are an allergic reaction in normal children and the elderly (DMD). In fact, there may be more severe in adults than children (DMD). Eczema in children often begins in childhood, with rash appearing on the face, neck, elbows and knees, (DMD). In some patients, may disappear by itself when the food that triggers an allergic reaction is removed from the diet, or it can be Extensiv?? Cover the whole body, (DMD). In extreme cases, the infection of the skin can develop, dystrophy (DMD).

The food allergy is characterized by an overreaction of the immune system to a substance or allergen protein that is eaten, breathed, injected, or touched, (AAFA). This immune overreaction can result in coughing, sneezing, itchy eyes, runny nose or throat (AAFA). In more severe cases, it can cause rashes, urticaria, hypotension, asthma attacks, difficulty breathing and even death (AAFA).

There is currently no cure for allergies, (AAFA), but with the exception of molecular TSLP official responsible for causing allergies, healing is possible. At present, allergies can be managed with caution and appropriate treatment (AAFA).

Allergies are present in individuals who are genetically predisposed to develop allergy (AAFA). For example, if a parent suffers from an allergy of any kind, there is a 1 in 3 chance that the child has an allergy, (AAFA). While on the other hand, if both parents have allergies, have 7 10 chance that their child has allergies, (AAFA). There is an increase in Americans suffering from allergies (AAFA). In fact, this is the most neglected diseases in America (AAFA). It is not even perceived by some as a disease!

Here we can see that all of the complications were mentioned in relation to allergy. Diabetes is still as allergic eczema. Therefore, the breakthrough in the study receive TSLP news for many people suffering from diseases related to allergy.


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